Particle sizes down to 10 μm with ± 5% deviation from the mean diameter.The platform technology has been divided into three subcategories: Stratµm™, Optimµm®, and Unisun®. Scaled multi-nozzles have been developed for two- and three-stream flow for producing solid microspheres (Figure A) and core-shell microcapsules (Figure B). It delivers on the promise of precision microparticles at a previously unachievable scale. The Precision Particle Fabrication™ platform was developed with industry in mind. Not to mention, the compatibility with a wide range of excipients and particle sizes enables unique functionality and product opportunities for creating first-in-class prescription formulations or matching complex modified release profiles of over-the-counter products. In Figure B, three-fluid nozzle adds further control over particle architecture by adjustment of “core” and “shell” flow rates, in addition to vibratory frequency. In Optimµm® technology, the carrier stream is comprised of air or nitrogen, which is analogous to spray congealing or prilling. In Stratµm™ technology, the carrier stream is comprised of water, which is analogous to emulsion processes. For any given mass flow rate, droplet size can be reduced simply by increasing the frequency of vibration. In Figure A, uses a two- or three- fluid vibrating nozzle with co-flowing axial “carrier” stream used to reduce jet diameter the use of both physical mechanisms simultaneously is patent-protected. ![]() Not to mention, Adare can achieve the same small sizes with a shell layer. Conversely, Adare’s process allows production of those same 25 micrometer particles (and much smaller) with sufficiently large orifice diameters. This is why all other scaleable uniform microsphere technologies are limited to a size of ~ 150 micrometers. Such a small orifice does not allow passage of viscous solutions or concentrated suspensions, fouls easily after a small number of uses, and is not a scalable approach. For instance, in other vibratory processes, producing uniform 25 micrometer droplets requires machining a ~13 micrometer hole in a nozzle body. Other vibratory technologies fall short because the smallest achievable particle size is governed by the orifice diameter. Seamlessly integrate into current processesĪdare uses two physical processes simultaneously to create uniform droplets: piezoelectric vibration and a co-flowing non-solvent “carrier” stream.Sustained, delayed, pulsatile release profiles.Proven capability to produce a variety of construction and release profiles: Macromolecules, polymers, nucleic acids, proteins.Small molecules (hydrophilic and hydrophobic).Production rates of kg/hr to kg/min, depending on the applicationįlexible and customizable to accommodate almost any active ingredient:.Controlled diameter from 10 μm up to 1 mm.Figure AĬontinuous-flow, high-volume nozzle technology with precise control over key attributes responsible for controlled release, including size, composition, coating, and materials. ![]() That means new ways to improve and differentiate your products, including their delivery, efficacy, and safety. With unprecedented control of particle size, previously hidden doors are suddenly open. Orbis’ technology is an elegant and robust solution with countless applications. ![]() Orbis was advised by Roydenne Partners while Beauchamps provided legal counsel on the deal, with Mazars providing tax advice.Precision Particle Fabrication™ technology produces uniform microspheres and microcapsules with narrow size distribution and precise control over particle structure. It was advised on the deal by law firms Matheson in Ireland and Gibson Dunn in the US “Who benefits? Clients. We both have expanded our reach into our target markets and added to our ability to provide world-class, expert-level consulting to the life science community.”Īstrix has been owned by private equity firm Quad-C Management since 2020. We want to expand in North America and Astrix wants to expand in Europe. Michael Gannon, founder and CEO of Orbis Life Sciences Consulting, stated: "The combination of Orbis and Astrix made a ton of sense. Research from Grandview suggests the global LIMS market is worth $2.1bn annually and expected to group by 7% each year to 2030. Astrix will launch in Europe as Astrix Europe following the acquisition of Orbis.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |